Biography

Dr. DeKoter is an Associate Professor in the Department of Microbiology & Immunology at Western University in London, Ontario. Dr. DeKoter is also a Scientist with the Division of Genetics & Development at the Children’s Hospital Research Institute in London, Ontario.  Dr. DeKoter obtained Bachelors degrees from Redeemer College (1988) and Western University (1990) and a PhD degree in Microbiology & Immunology from Western University (1996). Dr. DeKoter was a postdoctoral fellow with Dr. Harinder Singh, working at the Howard Hughes Medical Institute, University of Chicago from 1996-2001. He was an Assistant Professor of Molecular Genetics, Biochemistry, and Microbiology at the University of Cincinnati (Ohio) from 2001-2009 before moving to Western University in 2009.  Dr. DeKoter’s research program is focused on nuclear proteins called transcription factors, and how these proteins regulate gene expression, immune system development, and leukemia. This work is primarily done using mouse models. Dr. DeKoter’s research is funded by the CIHR, NSERC, and the Leukemia & Lymphoma Society of Canada.

Appointments

Associate Professor - Western University, Departments of Microbiology & Immunology and Oncology Scientist - Children’s Health Research Institute

Website

Research Group

Research Interest Area 

Immune system/disorders
Genetics

Research Overview

The goal of Dr. DeKoter’s research is to identify genetic causes of diseases affecting the immune system, including primary immunodeficiency and leukemia. These diseases are rare but devastating since there are few treatment options.

Members of the lab are working to determine how mutation of genes encoding transcription factors contributes to B cell acute lymphoblastic leukemia and acute myeloid leukemia. His research team is working hard to develop new cutting-edge therapies to fight these diseases.

Publications

Keywords

Leukemia, Lymphoma, Transcription Factors, Gene Regulation, Immune System Development