Biography

Education: 

1979-1984 D.V.M. (Lithuanian Academy of Veterinary Sciences
1984-1987 Ph.D.   (Institute of Biochemistry, Lithuanian Academy of Sciences)

 

Training:

1991-1995 Postdoctoral Fellow (LSU Medical Center, Shreveport, LA)
1995-1997 Postdoctoral Fellow  (Victoria Hospital Research Institute, London, ON, Canada)   

Professional and Academic Experience

1997-2000 Research Associate (Vascular Biology/Inflammation Program, Victoria Hospital Research Institute, London,ON, Canada)
2000-2003 Scientist (Vascular Biology/Inflammation Program, Victoria Hospital Research Institute, London, ON, Canada)
2002-2008 Assistant Professor (Cross-Appointment) Dept.Physiology, University of Western Ontario, London, ON, Canada
2007- 2013 Assistant Professor (Cross-Appointment) Dept. Medical Biophysics, University of Western Ontario, ON, Canada
2006- 2007 Assistant Director, Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada
2013- present Associate Professor, Dept. Medical Biophysics, University of Western Ontario, ON, Canada
2003present Scientist/Principal Investigator, Centre for Critical Illness Research, Victoria Hospital, Lawson Health Research Institute, London, ON, Canada
2008present Director, Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada

       

Profession

Scientist

Appointments

  • 2013 - present: Associate Professor, Dept. Medical Biophysics, University of Western Ontario, ON, Canada
  • 2008 - present: Director, Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada

 

Administrative Support

Janice Hoe (x55476)

Research Group

Research Interest Area 

Inflammation and inflammatory disease
Trauma

Research Overview

Sepsis/Systemic Inflammatory Response Syndrome (SIRS) is the body’s response to infectious (ie bacterial infection) or noninfectious (ie trauma, organ transplantation, burn) insult, resulting in multiple organ failure. Sepsis is the leading cause of death from infection worldwide.  Overwhelming activation of vascular endothelium and leukocytes are the key events contributing to sepsis/SIRS-induced injury and dysfunction of the affected organs.  My research focuses on the mechanisms of sepsis/SIRS-induced activation of neutrophilic leukocytes and organ-specific vascular endothelial cells with respect to generation of the oxidative/nitrosative/proteolytic stresses, production of inflammatory cytokines, up-regulation of the pro-adhesive phenotype, and subsequent changes in vascular permeability and recruitment of the inflammatory cells. Carbon monoxide releasing molecules (CORMs) are used as new treatment to counteract sepsis/SIRS-induced inflammatory response.

Publications

Keywords

Sepsis/SIRS, Ischemia/reperfusion, Vascular endothelium, Leukocytes, Cell signaling, Carbon monoxide, Leukocyte migration, Inflammation

Partners

Ongoing research partnership with:

Dr. Douglas D. Fraser - Traumatic Brain Injury, Sepsis, Blood-Brain-Barrier dysfunction, Diagnostic Biomarkers

Dr. Abdel Lawendy - Limb Compartment Syndrome

Drs. Partick Luke and Alp Sener - Carbon monoxide releasing molecules (CORMs) in kidney transplantation

Dr. Kevin Shoemaker - Cerebrovascular outcomes in ischemic heart disease patients undergoing cardiac rehabilitation