Professional and Academic Experience

Education and Training

1997-2003      Post-Doctoral Fellow Massachusetts General Hospital Cancer Centre, Harvard 
1992-1997 Ph.D. in Biochemistry  Dartmouth Medical School, Hanover, NH
1988-1992    B.Sc. in Biochemistry  Western University, London, ON

Professional Experience

2015 to present Distinguished Scientist Cancer Research Labs, London Regional Cancer Program  
2014 to present  Professor     Department of Biochemistry, Western University
2009 to 2014  Associate Professor  Department of Biochemistry, Western University
2013 to 2015    Senior Scientist     Cancer Research Labs, London Regional Cancer Program
2003 to 2013         Scientist  Cancer Research Labs, London Regional Cancer Program
2003 to present Scientist  Children’s Health Research  Institute
2003 to 2009 Assistant Professor    

Department of Biochemistry, Western University

 

Website

Research Group

Research Interest Area 

Cancer
Children's health

Research Overview

Regulation of the mammalian cell division cycle is critical to development and disease.  Loss of proliferative control during development is catastrophic, as it can lead to genome instability, apoptosis, and tissue degeneration.  Loss of cell cycle control is also important in disease pathology, as deregulated proliferation is a defining feature of cancer.  A key regulator of progression through the G1 phase of the cell cycle is the pathway controlled by the Retinoblastoma protein (pRB).  It functions beyond G1-S control and has implications for cancer pathogenesis, treatment choice, and outcome.  We are investigating this multifaceted pathway.

Publications

Keywords

cancer genetics, mouse models of cancer