Biography

I obtained an Honours Bachelor of Science from Dalhousie University in 1979, majoring in Biochemistry. In 1985, I obtained a Ph. D. in Biochemistry under the supervision of Dr. Carol Cass at the University of Alberta. I then undertook a 4-year post-doctoral fellowship with Dr. Yung-chi (Tommy) Cheng at the University of North Carolina-Chapel Hill. In 1989 I was hired as an Assistant Professor in the Department of Otolaryngology at the University of Western Ontario, and obtained a cross-appointment in the Department of Pharmacology and Toxicology (which has since become Physiology and Pharmacology).

Since then I have had several different appointments in the university, and taught courses on anti-infective and anti-cancer agents to students of Medicine, Dentistry, Nursing, and undergraduate science. In 1996 I joined the laboratory of Dr. James Koropatnick in the London Regional Cancer Centre. I currently still work in this laboratory as a Research Associate, and have appointments as Adjunct Professor in Oncology and Associate Scientist in the Lawson Health Research Institute.  I have coached hockey, soccer and baseball, and currently work on the annual tournament of the London Devilettes Hockey Association. I am a member of the Terry Fox Run organizing committee of London. I enjoy biking, guitar-playing , photography, hockey, and tasting craft beer. I am married (still) and have 2 grown children.

Professional and Academic Experience

Western University:

  • 2008 - present: Adjunct Professor, Department of Oncology
  • 1993 - 1996: Seminar Committee (Pharmacology and Toxicology)
  • 1990 - 2008: Honorary Lecturer/Assistant Professor/Adjunct Professor, Department of Physiology and Pharmacology
  • 1989 - 1994: Assistant Professor, Department of Otolaryngology
  • 1989 - 1994: Research Committee (Otolaryngology)

Lawson Health Research Institute

  • 1991 - 1994: Chairman, Continuing Education Committee

London Regional cancer Program

  • 2006- present: Safety Officer
  • 1999 - present: Chair, Journal Club
  • 1998 - 2000: Research Floor Representative, Y2K Preparation Committee. 

Supervision of Student Projects:

  • Department of Otolaryngology, 2 Residents
  • Department of Pharmacology and Toxicology, 4 Honours students
  • Department of Physiology & Pharmacology, Co-supervisor of one Graduate Student

Invited Oral Presentations - 18

Professional Membership:

  • 1996-present: Member, American Association for Cancer Research

Profession

Research Associate

Appointments

Adjunct Professor - Department of Oncology, The University of Western Ontario

Associate Scientist - Lawson Health Research Institute

Research Associate - Cancer Research Laboratory Program, London Regional Cancer Program - London Health Sciences Centre

Administrative Support

Cancer Research Laboratory Program Main Office (x53264)

Research Group

Research Interest Area 

Cancer
Drug discovery and development

Research Overview

My research is based on development of new anticancer agents, investigating compounds that improve the efficacy and selectivity of currently used chemotherapy agents as well as designing or screening novel agents against new drug targets.

Much of my work has focused on the use of antisense technology, using oligonucleotides or small interfering RNA (siRNA) to selectively decrease levels of proteins that either modulate drug activity or are targets for inhibition by a drug. It is hoped that these studies will lead to clinical use of this technology to improve patient outcome.

I am investigating the potential activity of natural product compounds (nutraceuticals) in preventing initiation and progression of cancer. I also conduct drug screening assays and investigate drug mechanisms on a contract basis.

Publications

Keywords

Cancer, Drugs, Antisense, Nutraceuticals, Cell Culture

Partners

Dr. James Koropatnick Dr. Mark Vincent Dr. David Rodenhiser Dr. Bekim Sadikovic